Related Experiment Video
Updated: Jul 13, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
Incorporating bioaccessibility in detailed quantitative human health risk assessments
1Land Quality Management Ltd & School of Geography, University of Nottingham, UK. paul@lqm.co.uk
Abstract:
Current English policy and practice allows, and in places encourages, site specific estimates of arsenic oral bioavailability to be used in detailed quantitative human health risk assessment. English land contamination legislation does not differentiate between natural and man made arsenic soil contamination. English planning guidance requires developers to demonstrate that new houses are fit for purpose, including ensuring that there are no unacceptable risks to human health from soil contaminants. Naturally occurring arsenic in soils at a new housing site in southwest England was demonstrated not to pose unacceptable risk to human health by site specific estimates of bioavailability and region specific estimates of soil to plant uptake factors. Independent lines of evidence were used to justify the arsenic exposure factors for oral bioavailability and soil to plant uptake. Using site specific assessment criteria based on tools and information that give a better estimate of the actual exposure avoided both unnecessary public concern and considerable local authority expenditure across the outcrop of such soils as part of their legal duties.
More Related Videos
16:02Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
08:00Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays
Published on: December 4, 2016
Related Concept Videos
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Toxicity Testing in Animals
Bioavailability Study Design: Healthy Subjects Versus Patients
Bioavailability Study Design: Absolute Versus Relative Bioavailability
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
Bioavailability Study Design: Single Versus Multiple Dose Studies