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Subcortical functioning in obsessive-compulsive disorder: an exploratory EEG coherence study.

Pushpal Desarkar¹, Vinod Kumar Sinha, Karuppiah Jagadheesan

¹Centre for Cognitive Neuroscience, Central Institute of Psychiatry, Ranchi, Jharkhand, India. pushpalds@yahoo.com

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry

|July 27, 2007

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Electroencephalography (EEG) coherence revealed increased theta band activity in the fronto-occipital region of patients with obsessive-compulsive disorder (OCD). This suggests sub-cortical hyperactivity, supporting OCD dysfunction theories.

Area of Science:

Neuroscience
Clinical Psychology
Biomedical Engineering

Background:

Obsessive-compulsive disorder (OCD) research lacks quantitative electroencephalography (EEG) coherence studies on sub-cortical structures.
Understanding electrophysiological functional integrity is crucial for OCD pathophysiology.

Purpose of the Study:

To investigate EEG coherence in adult OCD patients compared to healthy controls.
To explore sub-cortical network activity using EEG coherence in specific brain regions.

Main Methods:

EEG coherence was measured in delta, theta, alpha, beta1, and beta2 bands.
Coherence was analyzed across four distant brain regions: anterior interhemispheric, posterior interhemispheric, fronto-temporal, and fronto-occipital.
20 adult OCD patients and 19 matched healthy controls participated.

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Main Results:

OCD patients showed significantly increased theta band EEG coherence in the fronto-occipital region compared to controls (P = 0.045).
This increased coherence did not correlate with medication status or disease severity.

Conclusions:

The findings suggest hyperactivity within sub-cortical circuitry in OCD patients.
This EEG coherence study supports the sub-cortical dysfunction hypothesis of OCD.
Results align with existing neuro-imaging findings in OCD.