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Updated: Jul 13, 2026

Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) Mass Spectrometry
Published on: June 10, 2018
A novel software tool for copolymer characterization by coupling of liquid chromatography with matrix-assisted laser
Steffen M Weidner1, Jana Falkenhagen, Sergey Maltsev
1Federal Institute for Materials Research and Testing (BAM), Dept. I Analytical Chemistry, Reference Materials, Richard-Willstaetter-Strasse 11, D-12489 Berlin, Germany. steffen.weidner@bam.de
Abstract:
The results of copolymer characterization by coupling of chromatography and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) techniques and subsequent calculation of copolymer composition using a novel software tool 'MassChrom2D' are presented. For high-resolution mass analysis copolymer samples were fractionated by means of liquid adsorption chromatography (LAC). These fractions were investigated off-line by MALDI-TOF MS. Various mono-n-butyl ethers of polyethylene oxide-polypropylene oxide copolymers (PEO-co-PPO) were investigated. As well as the copolymer composition presented in two-dimensional plots, the applied approach can give additional hints on specific structure-dependent separation conditions in chromatography.
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