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Related Experiment Video

Updated: Jul 13, 2026

Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging

Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging

Published on: December 9, 2021

Time-resolved MR angiography with limited projections.

Yuexi Huang¹, Graham A Wright

¹Department of Medical Biophysics, University of Toronto, Toronto, Canada. huangyx@sten.sunnybrook.utoronto.ca

Magnetic Resonance in Medicine

|July 27, 2007

Summary

Highly-constrained backprojection (HYPR) improves time-resolved MRI reconstruction. Computer simulations and canine studies show HYPR has potential for clinical dynamic contrast-enhanced MR angiography (MRA) despite minor intensity modulations.

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Phase Contrast Magnetic Resonance Imaging in the Rat Common Carotid Artery

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Last Updated: Jul 13, 2026

Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging

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Published on: December 9, 2021

Phase Contrast Magnetic Resonance Imaging in the Rat Common Carotid Artery

Phase Contrast Magnetic Resonance Imaging in the Rat Common Carotid Artery

Published on: September 5, 2018

Area of Science:

Medical Imaging
Biomedical Engineering
Radiology

Background:

Dynamic contrast-enhanced MR angiography (MRA) requires robust reconstruction methods.
Time-resolved MRA is crucial for visualizing vascular dynamics.
Existing methods may face challenges with data sparsity and temporal resolution.

Purpose of the Study:

To evaluate the highly-constrained backprojection (HYPR) reconstruction method for time-resolved MRA.
To assess HYPR's performance concerning data sparsity and temporal dynamics.
To demonstrate HYPR's application in 3D time-resolved abdominal MRA.

Main Methods:

Computer simulations of signal modulations in dynamic contrast-enhanced MRA.
In vivo studies using gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) in a canine model.
Evaluation of HYPR reconstruction under varying contrast dynamics and acquisition orders.

Main Results:

HYPR reconstruction can introduce intensity modulations due to signal interference from large vessels and background tissue.
Artifacts are primarily intensity-based, with minimal impact on structural diagnosis.
Increasing projections per time point reduces temporal blur but can increase corruption.
Uniformly interleaved acquisition orders, like bit-reversed, are crucial for artifact reduction.

Conclusions:

HYPR reconstruction demonstrates potential for improving time-resolved MRA.
The method offers a high signal-to-noise ratio with manageable artifacts.
HYPR shows promise for enhancing clinical applications of 3D time-resolved MRA.