Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dose reduction for cardiac CT using a registration-based approach.

Marcin Wierzbicki1, Gérard M Guiraudon, Douglas L Jones

  • 1Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, P.O. Box 5015, N6A 5K8, London, Ontario, Canada.

Medical Physics
|July 28, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physically validated mitral valve models for surgical simulation: Bridging anatomy, pathology, and practice.

JTCVS open·2026
Same author

Development and feasibility testing of a dynamic image-derived simulation framework for assessing left atrioventricular valve repair strategies.

International journal of computer assisted radiology and surgery·2026
Same author

Confusion and human errors in locating synthetic frog calls: Insights into the evolution of a vocal communication signal.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2026
Same author

JP2 and JCN Crosstalk Abrogate MURF1-Mediated JCN Ubiquitination and Degradation in Cardiomyocytes.

JACC. Basic to translational science·2026
Same author

Quality of Life of Stereotactic Versus Hypofractionated Radiation Therapy for Inoperable Stage I Non-Small Cell Lung Cancer: Results From the LUSTRE Trial.

International journal of radiation oncology, biology, physics·2025
Same author

Dosimetric Outcomes of Stereotactic Body Radiation Therapy to Ultracentral Lung Tumors: Lessons From the SUNSET Trial.

International journal of radiation oncology, biology, physics·2025
Same journal

Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

Medical physics·2026
Same journal

Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

Medical physics·2026
Same journal

Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

Medical physics·2026
Same journal

Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

Medical physics·2026
Same journal

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026
Same journal

Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

Medical physics·2026
See all related articles

This study presents a new method to reduce radiation dose in cardiac CT imaging. By using ECG-gated dose modulation, high-quality 4D cardiac images can be reconstructed with significantly lower patient radiation exposure.

Area of Science:

  • Medical Imaging
  • Radiology
  • Cardiovascular Imaging

Background:

  • Increasing CT clinical applications and smaller voxel sizes lead to higher radiation exposure.
  • ECG-driven tube current modulation is used in cardiac imaging to reduce dose.
  • Maintaining image quality during dose reduction is a significant challenge.

Purpose of the Study:

  • To develop a method for reconstructing high-quality 4D cardiac CT data from ECG-modulated, lower-dose acquisitions.
  • To enable significant radiation dose reduction in cardiac CT while preserving image quality.

Main Methods:

  • Utilized middiastole (MD) phase images acquired at full dose.
  • Registered the full-dose MD image to lower-dose images from other cardiac phases.
  • Applied derived transformations to warp the MD frame, reconstructing a full 4D cardiac image dataset.

Related Experiment Videos

  • Interpolated transformations for enhanced temporal sampling or arbitrary time point image generation.

    • Main Results:

    • Successfully reconstructed high-quality 4D cardiac images from low-dose acquisitions.
    • Achieved substantial dose reduction, requiring as little as 10% of the total dose.
    • Maintained image quality with minimal spatial error (1 mm) and intensity value errors within image noise levels.

    Conclusions:

    • The proposed technique offers considerable radiation dose reduction compared to standard cardiac CT protocols.
    • The method effectively preserves the quality of 4D cardiac imaging data.
    • This approach addresses the emerging dose problem in CT, particularly for cardiac applications.