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Updated: Jul 13, 2026

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
Published on: September 5, 2019
Three-dimensional Monte Carlo simulations of intracellular diffusion and reaction of signaling proteins
1Department of Applied Physics, Chalmers University of Technology, S-41296 Göteborg, Sweden. zhdanov@catalysis.ru
Abstract:
We show that the Monte Carlo technique makes it possible to perform three-dimensional simulations of intracellular protein-mediated signal transduction with realistic ratio of the rates of protein diffusion and association with genes. Specifically, we illustrate that in the simplest case when the protein degradation and phosphorylation/dephosphorylation are negligible the distribution of the first passage time for this process is close to exponential provided that the number of target genes is between 1 and 100.
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