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Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis

Maja Zivković1, Tamara Djurić, Evica Dincić

  • 1Vinca Institute of Nuclear Sciences, Laboratory for Radiobiology and Molecular Genetics, Belgrade, Serbia. majaz@vin.bg.ac.yu

Journal of Neuroimmunology
|July 28, 2007
PubMed

Insights

The study investigated the matrix metalloproteinase-9 (MMP-9) gene polymorphism in multiple sclerosis (MS) patients. A lower frequency of the T allele was observed in female MS patients, suggesting a potential role in MS susceptibility.

Area of Science:

  • Neuroimmunology
  • Genetics
  • Biochemistry

Background:

  • Matrix metalloproteinase-9 (MMP-9) is implicated in multiple sclerosis (MS) pathogenesis.
  • MMP-9 may influence T cell migration and myelin breakdown, key processes in MS.

Purpose of the Study:

  • To investigate the association between MMP-9 gene polymorphisms (-1562 C/T) and MS susceptibility and severity.
  • To analyze the role of MMP-9 genetic variations in a Serbian MS patient cohort.

Main Methods:

  • Genotyping of the MMP-9 -1562 C/T polymorphism in 187 Serbian MS patients.
  • Statistical analysis to assess the relationship between genotypes, MS susceptibility, and disease severity (Multiple Sclerosis Severity Score - MSSS).

Main Results:

  • A statistically significant decrease in T allele carriers was found in female MS patients (p = 0.01).
  • A trend towards a lower MSSS was observed in T allele carriers (CC vs. CT+TT).

Conclusions:

  • The MMP-9 -1562 C/T gene polymorphism may be associated with MS susceptibility, particularly in females.
  • Further research across diverse populations is necessary to confirm the influence of MMP-9 gene polymorphism on MS.

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