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Tying the knot: making of lasso peptides

Gabriele Bierbaum1, Andrea Jansen

  • 1Institute for Medical Microbiology, Immunology and Parasitology, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.

Chemistry & Biology
|July 28, 2007
PubMed

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Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...