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Updated: Jul 13, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Antibacterial prescribing in primary care.

Irene Petersen¹, Andrew C Hayward,

¹UCL Centre for Infectious Disease Epidemiology, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK.

The Journal of Antimicrobial Chemotherapy

|September 14, 2007

Summary

General practice antibiotic prescribing data reveals common indications like upper respiratory infections. While some antibiotic use may be high, chosen medications generally align with first-line treatment guidelines.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

General Practice
Pharmacology
Infectious Disease

Background:

Antibiotic prescribing in general practice requires monitoring to ensure adherence to guidelines.
Existing national data lacks specific diagnostic information for antibiotic prescriptions.
The General Practice Research Database offers a valuable resource for detailed prescribing analysis.

Purpose of the Study:

To identify the leading indications for antibiotic prescriptions in general practice.
To assess the appropriateness of antibiotic selection for common conditions.

Main Methods:

Utilized the General Practice Research Database to analyze antibiotic prescribing patterns.
Identified and ranked the top 10 indications for antibacterial drug use.

Main Results:

The leading indications included upper respiratory tract infection (RTI), lower RTI, sore throat, and urinary tract infection.
Other common diagnoses were otitis media, conjunctivitis, skin infections, sinusitis, otitis externa, and impetigo.
Antibiotics prescribed were typically aligned with recommended first-line treatments, despite potentially high prescribing levels for certain conditions.

Conclusions:

Antibiotic prescribing for common infections in general practice is substantial.
While prescribing levels may warrant review for some conditions, the choice of antibiotics generally follows established guidelines.