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Type 2 diabetes in children in the Netherlands: the need for diagnostic protocols
Joost Rotteveel1, Eline J Belksma, Carry M Renders
1Department of Pediatrics, Institute for Clinical and Experimental Neuroscien ces, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. j.rotteveel@vumc.nl
Insights
Childhood obesity is rising, leading to type 2 diabetes. Dutch pediatricians diagnosed few type 2 diabetes cases, with many misclassified, highlighting a need for better diagnostic protocols.
Area of Science:
- Pediatrics
- Endocrinology
- Public Health
Background:
- Childhood obesity is a growing global concern.
- This trend is also evident in the Netherlands, potentially increasing type 2 diabetes incidence.
- Type 2 diabetes in children requires specific diagnostic and management strategies.
Purpose of the Study:
- To assess the number of children diagnosed with type 2 diabetes by pediatricians in the Netherlands.
- To evaluate the accuracy of type 2 diabetes diagnoses made in pediatric daily practice.
- To identify potential misclassifications in type 2 diabetes diagnoses among children.
Main Methods:
- Utilized the Dutch Paediatric Surveillance Unit, a nationwide register, for new diabetes mellitus cases in 2003-2004.
- Collected socio-demographic and clinical data via questionnaires.
- Sent a second questionnaire for clarification on inconclusive or type 1 diabetes diagnoses in overweight/obese children.
Main Results:
- 1142 new diabetes cases reported; 943 eligible for analysis.
- Initially, 1.5% (14 patients) were reported with type 2 diabetes; only 7 met ADA criteria.
- After follow-up, 2.4% of patients were classified as having type 2 diabetes, with significant misclassification observed.
Conclusions:
- A notable discrepancy exists between pediatricians' diagnoses and ADA criteria for type 2 diabetes.
- A considerable proportion of reported cases were misclassified, indicating diagnostic challenges.
- Development of standardized programs for type 2 diabetes prevention, diagnosis, and classification in pediatric practice is essential.
Objective:
The worldwide trend towards obesity in childhood is also observed in the Netherlands and one of the consequences may be type 2 diabetes. In this study, we assessed the number of children with type 2 diabetes, diagnosed by paediatricians, in the Netherlands.
Methods:
In 2003 and 2004 the Dutch Paediatric Surveillance Unit, a nationwide paediatric register, was used to assess new cases of diabetes mellitus. Data on socio-demographic and clinical characteristics were collected by means of a questionnaire. A second questionnaire was sent to the reporting paediatrician if the diagnosis was inconclusive or if the diagnosis was type 1 diabetes in combination with overweight or obesity, according to international criteria.
Results:
During the 24 months of registration, the paediatricians reported 1142 new cases of diabetes, 943 of which were eligible for analysis. Initially, 14 patients (1.5%) were reported with type 2 diabetes. Only seven of these patients were classified as type 2 diabetes according to the ADA criteria, as information on C-peptides or antibodies was often missing. Based on clinical characteristics, the other seven patients were very likely to have type 2 diabetes. After the second questionnaire, six more patients met the ADA criteria and two were very likely to have type 2 diabetes. Most of the patients were female (95%), 14% were of Turkish and 18% of Moroccan origin.
Conclusion:
This study shows a discrepancy between the number of patients with type 2 diabetes diagnosed by paediatricians in daily practice and diagnosed according to the ADA criteria. Moreover, a considerable amount of reported patients were misclassified. Finally, 2.4% patients were classified as (very likely) type 2 diabetes. The development of programmes and protocols for prevention, diagnosis and classification applicable in daily practice is warranted.
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