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Related Experiment Videos

Patch tests in adverse cutaneous drug reaction.

C Balachandran1, Shruthakirthi D Shenoi, Dipak Sarkar

  • 1Department of Skin & S.T.D., Kasturba Medical College, Manipal-576119, Karnataka, India.

Indian Journal of Dermatology, Venereology and Leprology
|July 28, 2007
PubMed
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Patch testing identified the cause of adverse cutaneous drug reactions in 42.85% of patients. While common in maculopapular cases, severe reactions like Stevens-Johnson syndrome showed negative results.

Area of Science:

  • Dermatology
  • Pharmacology
  • Allergy

Background:

  • Adverse cutaneous drug reactions (ACDRs) are common.
  • Accurate diagnosis is crucial for patient management.
  • Patch testing is a diagnostic tool for delayed hypersensitivity reactions.

Purpose of the Study:

  • To evaluate the efficacy of patch testing in diagnosing ACDRs.
  • To identify common drugs causing ACDRs.
  • To correlate patch test results with specific ACDR morphologies.

Main Methods:

  • Twenty-one patients with a history of ACDR were enrolled.
  • Patch testing was performed using 23 common drugs at 5% concentration in petrolatum.
  • Reactions were assessed for positivity to incriminated and non-incriminated drugs.

Related Experiment Videos

Main Results:

  • Nine patients (42.85%) had positive patch tests to the suspected drugs.
  • Three patients (14.28%) showed positive reactions to unrelated drugs.
  • Highest positivity (50%) was observed in maculopapular drug eruptions.
  • Stevens-Johnson syndrome and exfoliative dermatitis cases yielded negative results.

Conclusions:

  • Patch testing is a valuable diagnostic method for ACDRs, particularly maculopapular types.
  • Negative patch test results in severe ACDRs warrant further investigation.
  • Identifying causative agents through patch testing aids in preventing future reactions.