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Frictional amyloidosis in Oman--a study of ten cases

Venkataram Mysore1, Shivayogi R Bhushnurmath, David E Muirhead

  • 1Department of Dermatology & Genito Urinary Medicine, Al Nahdha Hospital and Baushar Polyclinic, Muscat, Bahrain.

Indian Journal of Dermatology, Venereology and Leprology
|July 28, 2007
PubMed

Insights

Friction can cause macular amyloidosis, a skin pigmentation condition. Electron microscopy is more reliable than histochemical stains for diagnosing this frictional amyloidosis.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Macular amyloidosis causes skin pigmentation with an unclear cause.
  • Friction is a suspected cause of early lesions, termed frictional amyloidosis.

Purpose of the Study:

  • To investigate the role of friction in macular amyloidosis.
  • To evaluate diagnostic methods for amyloid detection.

Main Methods:

  • Studied 10 patients with suspected macular amyloidosis.
  • Collected detailed patient histories and clinical data.
  • Performed biopsies for histochemistry and electron microscopy.

Main Results:

  • Nine of ten patients reported prolonged friction from various objects.
  • Histochemical stains detected amyloid in 6/10 cases.
  • Electron microscopy detected amyloid in the remaining 4/10 cases, showing characteristic fiber aggregates.

Conclusions:

  • Friction plays a significant role in causing macular amyloidosis.
  • Histochemical stains can be inconsistent for amyloid detection.
  • Electron microscopy is a valuable tool for confirming frictional amyloidosis diagnosis.

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