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Nicolau syndrome.

Saheb D Masthan1, Salome, Madhav

  • 1Department of Dermatology, Government General Hospital Kurnool-518 002, Andhra Pradesh, India.

Indian Journal of Dermatology, Venereology and Leprology
|July 28, 2007
PubMed
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A rare case of Nicolau syndrome occurred in a woman after receiving an intramuscular injection of diclofenac sodium. This adverse drug reaction highlights potential risks associated with this common anti-inflammatory medication.

Area of Science:

  • Pharmacology
  • Dermatology
  • Clinical Medicine

Background:

  • Diclofenac sodium is a widely used nonsteroidal anti-inflammatory drug (NSAID).
  • Intramuscular injections are a common route of administration for diclofenac sodium.
  • Nicolau syndrome is a rare but serious adverse reaction characterized by skin necrosis.

Purpose of the Study:

  • To report a case of Nicolau syndrome following intramuscular diclofenac sodium injection.
  • To raise awareness of this potential adverse drug reaction.

Main Methods:

  • Case report detailing the clinical presentation and management.
  • Review of relevant literature on Nicolau syndrome and diclofenac sodium injections.

Main Results:

Related Experiment Videos

  • The patient developed characteristic lesions of Nicolau syndrome post-injection.
  • The condition was managed with supportive care.

Conclusions:

  • Intramuscular diclofenac sodium can precipitate Nicolau syndrome.
  • Healthcare providers should be vigilant for this rare complication.