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A comparative clinical study of sisomicin cream versus mupirocin ointment in pyodermas

Chetan Oberai1, S Shailendra, Darchan Dalal

  • 1Dept. of Skin, STD & Leprosy, Grant Medical College & Sir J. J. Group of Hospitals J. J. Road, Byculla, Mumbai, India.

Indian Journal of Dermatology, Venereology and Leprology
|July 28, 2007
PubMed

Insights

Sisomicin cream demonstrated faster and more significant improvement in pyoderma symptoms compared to mupirocin ointment. Both topical antibiotics were effective and safe for treating skin infections.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Pyodermas are common bacterial skin infections.
  • Topical antibiotics are a standard treatment for pyodermas.
  • Sisomicin and mupirocin are commonly used topical antibiotics.

Purpose of the Study:

  • To compare the efficacy and safety of sisomicin cream versus mupirocin ointment for pyoderma treatment.
  • To evaluate the speed and degree of symptom improvement.
  • To assess patient-reported outcomes.

Main Methods:

  • A comparative study involving 290 evaluable patients with primary or secondary pyodermas.
  • Treatment with either sisomicin cream (0.1%) or mupirocin ointment (2%).
  • Assessment of clinical signs (erythema, oedema, etc.) and pathogen eradication.

Main Results:

  • Both treatments improved clinical scores, with sisomicin showing quicker and more pronounced effects.
  • Higher rates of complete lesion clearing were observed with sisomicin on days 4, 8, and 14.
  • Sisomicin was rated excellent by 75% of patients, versus 59% for mupirocin.

Conclusions:

  • Sisomicin and mupirocin are effective and safe topical treatments for pyodermas.
  • Sisomicin therapy offers faster and more substantial relief from signs and symptoms.
  • Sisomicin may be a preferred option for pyoderma management due to superior clinical outcomes.

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