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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
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Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

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Related Experiment Video

Updated: Jul 13, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Acquired (digital) fibrokeratoma.

A K Jaiswal1, M Chatterjee

  • 1Department of Skin and STD, Base Hospital, Barrockpore, West Bengal-743 101, India.

Indian Journal of Dermatology, Venereology and Leprology
|July 28, 2007
PubMed
Summary

Acquired digital fibrokeratoma is a rare skin condition. This report details a unique case presentation in India, highlighting an unusual location for this disorder.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Acquired digital fibrokeratoma (ADF) is an uncommon benign skin neoplasm.
  • It typically presents as a solitary, firm papule or nodule on the digits.
  • ADF is infrequently documented in Indian medical literature.

Purpose of the Study:

  • To report a case of acquired digital fibrokeratoma.
  • To emphasize its occurrence at an atypical anatomical site.
  • To contribute to the limited Indian literature on this condition.

Main Methods:

  • Clinical presentation and diagnostic evaluation of the patient.
  • Histopathological examination of the lesion.
  • Review of relevant medical literature.

Main Results:

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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

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Published on: December 19, 2019

  • A case of acquired digital fibrokeratoma was identified.
  • The lesion was located at an unusual site, not typically associated with ADF.
  • Histopathology confirmed the diagnosis of fibrokeratoma.

Conclusions:

  • Acquired digital fibrokeratoma can manifest at unusual body sites.
  • This case expands the known clinical spectrum of ADF.
  • Further case reports are needed to understand the full range of ADF presentations, particularly from the Indian subcontinent.