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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
Published on: January 28, 2021
Study of serum lipids in leprosy
Anju Gupta1, Ravindra V Koranne, Nancy Kaul
1Department of Dermatology and Venereology, Lady Hardinge Medical College and Associated Smt. Sucheta Kripalani Hospital, New Delhi-110 001, India.
Indian Journal of Dermatology, Venereology and Leprology
|July 28, 2007
Summary
Leprosy disease alters lipid metabolism, affecting triglyceride, total cholesterol, HDL, and LDL levels. These changes occur independently of liver function and specific leprosy classifications.
Area of Science:
- Biochemistry
- Infectious Diseases
- Clinical Medicine
Background:
- Leprosy is a chronic infectious disease primarily affecting the skin, peripheral nerves, and upper respiratory tract.
- Understanding the metabolic impact of leprosy is crucial for comprehensive patient management.
Purpose of the Study:
- To investigate alterations in lipid profiles in untreated leprosy patients.
- To determine if leprosy disease per se affects lipid metabolism.
Main Methods:
- A study group of 50 untreated leprosy patients and 50 healthy controls was analyzed.
- Lipid profiles including triglyceride, total cholesterol, HDL, LDL, and VLDL cholesterol were measured.
- The Ridley and Jopling system was used for leprosy classification.
Main Results:
- Leprosy patients showed statistically decreased levels of total cholesterol, HDL, and LDL cholesterol compared to controls.
- Triglyceride levels were lower in TT leprosy and insignificantly increased in BL and LL groups.
- No significant correlation was found between leprosy type, bacterial indices, and lipid fraction levels.
Conclusions:
- Leprosy disease is associated with significant alterations in lipid metabolism.
- These lipid changes occur independently of liver function tests.
- No direct correlation was established between specific leprosy types and the observed lipid alterations.
