Related Experiment Video
Updated: Jul 13, 2026

06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Disseminated superficial porokeratosis
A Gnaneshwar Rao1, T S S Lakshmi, S Haritha
1Department of Dermatology, Osmania General Hospital, Hyderabad-500 012, India.
Indian Journal of Dermatology, Venereology and Leprology
|July 28, 2007
Summary
Disseminated superficial porokeratosis is a rare skin condition characterized by itchy, scaling plaques. This case highlights its presentation in a diabetic patient, confirmed by skin biopsy.
Area of Science:
- Dermatology
- Histopathology
Background:
- Disseminated superficial porokeratosis (DSP) is a rare genodermatosis.
- It presents as multiple small, scaling papules that enlarge into annular or linear plaques with a characteristic raised, thread-like border.
Purpose of the Study:
- To describe a case of disseminated superficial porokeratosis in a diabetic patient.
- To emphasize the importance of clinical examination and biopsy for diagnosis.
Main Methods:
- Clinical presentation of a 65-year-old male diabetic patient with a 10-year history of itchy, erythematous, and hyperpigmented plaques.
- Dermatological examination revealing characteristic plaques with raised borders and furrows.
- Skin biopsy to confirm the diagnosis.
Main Results:
- The patient presented with extensive erythematous and hyperpigmented plaques with scaling and crusting.
- A key finding was a raised, thread-like margin with a furrow on a forearm plaque.
- Histopathological examination confirmed disseminated superficial porokeratosis.
Conclusions:
- Disseminated superficial porokeratosis can present with varied morphology.
- Early and accurate diagnosis through clinical suspicion and skin biopsy is crucial for appropriate management.
Related Concept Videos
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Papillary Dermis
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cells of the Epidermis
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Reticular Dermis
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Desmosomes
The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions areĀ essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
