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Histoid leprosy with ENL reaction.

Suresh K Sharma1, Namita Rath, R K Gautam

  • 1Department of Skin and STD, Dr RML Hospital, New Delhi-110 001, India.

Indian Journal of Dermatology, Venereology and Leprology
|July 28, 2007
PubMed
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Histoid leprosy can manifest with firm nodules that may suppurate during multidrug therapy (MDT). These nodules can exhibit erythema nodosum leprosum (ENL), a rare but significant finding in this leprosy form.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pathology

Background:

  • Histoid leprosy is a rare form of Mycobacterium leprae infection.
  • Cutaneous and subcutaneous nodules are characteristic manifestations.
  • Multidrug therapy (MDT) is the standard treatment.

Purpose of the Study:

  • To report a case of histoid leprosy with unusual erythema nodosum leprosum (ENL) development.
  • To highlight the histopathological features of ENL in this context.

Main Methods:

  • Clinical presentation of a 23-year-old male patient with histoid leprosy.
  • Observation of nodule suppuration during MDT.
  • Histopathological examination of suppurated nodules.

Main Results:

Related Experiment Videos

  • The patient presented with firm cutaneous and subcutaneous nodules.
  • Some nodules suppurated following initiation of MDT.
  • Histopathology confirmed erythema nodosum leprosum (ENL) in the suppurated nodules.

Conclusions:

  • Erythema nodosum leprosum (ENL) can occur in histoid leprosy, even after the initiation of MDT.
  • This case underscores the importance of histopathological examination for diagnosing rare leprosy complications.