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Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
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Histoid leprosy with filariasis.

Kamal Aggrawal1, V K Jain, Surbhi Dayal

  • 1Department of Skin, V. D and Leprosy, Pt. BDS Postgraduate Institute of Medical Sciences, Rohtak-1 24001 (Haryana), India.

Indian Journal of Dermatology, Venereology and Leprology
|July 28, 2007
PubMed
Summary

A rare case of histoid leprosy emerged in a patient undergoing diethylcarbamazine citrate treatment for filariasis. This "de-novo" development highlights a potential, unusual interaction between the two diseases and their treatments.

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Area of Science:

  • Medical Parasitology
  • Infectious Diseases
  • Dermatology

Background:

  • Filariasis is a parasitic disease affecting millions globally.
  • Leprosy is a chronic infectious disease caused by Mycobacterium leprae.
  • Co-infections and unusual disease presentations pose diagnostic and therapeutic challenges.

Purpose of the Study:

  • To report a unique case of de-novo histoid leprosy.
  • To describe the clinical presentation and management of a patient with co-existing filariasis and leprosy.
  • To discuss the potential implications of filariasis treatment on leprosy development.

Main Methods:

  • Case report.
  • Review of patient's medical history and treatment regimen.
  • Clinical and histopathological examination for diagnosis.

Main Results:

  • A patient treated for filariasis with diethylcarbamazine citrate developed histoid leprosy.
  • The leprosy presented as a de-novo condition during filariasis treatment.
  • This case suggests a possible link or interaction between filariasis, its treatment, and the development of histoid leprosy.

Conclusions:

  • The occurrence of de-novo histoid leprosy during filariasis treatment is a rare event.
  • Further investigation may be warranted to understand the pathogenetic mechanisms.
  • This case underscores the importance of vigilance for unusual dermatological manifestations in patients with parasitic infections and those undergoing treatment.