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The multi-functional cellular adhesion molecule CD44 is regulated by the 8;21 chromosomal translocation

L F Peterson1, Y Wang, M-C Lo

  • 1Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.

Leukemia
|July 28, 2007
PubMed
Summary

The 8;21 translocation in acute myeloid leukemia (AML) involves the AML1-ETO9a splice variant, which upregulates CD44 expression. This links the translocation to cell adhesion molecule regulation crucial for AML growth.

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