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Insulin dependent diabetes 1991.

E Connor1, J Silverstein, N Maclaren

  • 1Department of Pediatrics, University of Florida College of Medicine, Gainesville.

The Journal of the Florida Medical Association
|November 1, 1991
PubMed
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Autoimmune destruction of pancreatic beta cells causes insulin-dependent diabetes (IDD). Early detection of diabetes-related antibodies in relatives can identify those at high risk for developing IDD, enabling preventative interventions.

Area of Science:

  • Immunology
  • Endocrinology
  • Diabetes Research

Background:

  • Insulin-dependent diabetes (IDD) typically stems from autoimmune destruction of pancreatic beta cells.
  • Autoantibodies to islet cell constituents and insulin are markers for IDD prediction and classification.
  • Approximately 4-5% of relatives of individuals with IDD possess these autoantibodies.

Purpose of the Study:

  • To investigate the potential of early immunosuppressive therapies to prevent beta cell destruction in individuals at high risk for IDD.
  • To screen family members for diabetes-related autoantibodies and identify those eligible for a preventative trial.

Main Methods:

  • Screening of relatives for islet cell antibodies and insulin autoantibodies.
  • Enrollment of antibody-positive relatives at increased risk into a multicenter prevention trial.

Related Experiment Videos

  • Administration of immunosuppressive therapies to potentially halt autoimmune attack on beta cells.

    • Main Results:

    • Identification of relatives with diabetes-related autoantibodies, indicating elevated risk for IDD.
    • Ongoing multicenter trial in Florida to evaluate the efficacy of pre-onset intervention.
    • Data collection on antibody titers and age as predictors of IDD development.

    Conclusions:

    • Early detection of autoantibodies in relatives can identify individuals at high risk for IDD.
    • Preventative strategies, including immunosuppression, may halt beta cell destruction and delay or prevent clinical diabetes.
    • A multicenter trial is actively recruiting participants to test these preventative measures.