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Related Concept Videos

Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

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Related Experiment Video

Updated: Jul 13, 2026

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica
07:47

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica

Published on: February 10, 2023

Cytoprotection and healing: two unequal brethren.

F Halter1, B Peskar, K D Rainsford

  • 1Department of Medicine, Gastrointestinal Unit, University of Bern, Inselspital, Bern, Switzerland.

Inflammopharmacology
|January 1, 1997
PubMed
Summary

New NSAIDs (nonsteroidal anti-inflammatory drugs) show reduced gastrointestinal toxicity but may still impair ulcer healing. Differentiating cytoprotective from healing effects is crucial for developing effective ulcer therapies.

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Protocol to Create Chronic Wounds in Diabetic Mice
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Last Updated: Jul 13, 2026

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica
07:47

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica

Published on: February 10, 2023

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause gastrointestinal ulcers.
  • Cytoprotection strategies aim to prevent NSAID-induced ulcers.
  • Novel NSAID formulations have been developed to reduce gastrointestinal toxicity.

Purpose of the Study:

  • To evaluate whether novel NSAID formulations with diminished gastrointestinal toxicity also preserve ulcer healing properties.
  • To distinguish between cytoprotective and ulcer healing effects of drugs targeting the cyclo-oxygenase pathway.

Main Methods:

  • Review of recent studies on novel NSAID formulations, including combined lipoxygenase/cyclo-oxygenase inhibitors, NO-donor NSAIDs, and COX-2 inhibitors.
  • Analysis of data from experimental models, particularly chronic ulcer models.
  • Comparison of cytoprotective activity with effects on ulcer healing.

Main Results:

  • While novel NSAID formulations demonstrate reduced gastrointestinal toxicity, this does not guarantee unimpaired ulcer healing.
  • Prostaglandins, at cytoprotective doses, do not accelerate ulcer healing.
  • Evidence suggests that some new NSAIDs may interfere with ulcer healing despite improved gastrointestinal tolerance.

Conclusions:

  • It is essential to differentiate between the cytoprotective and ulcer healing properties of NSAIDs.
  • The development of novel NSAIDs requires careful consideration of their impact on both gastrointestinal safety and therapeutic efficacy in ulcer healing.