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Related Experiment Videos

Long-term graft function after allogeneic islet transplantation.

Jonathan R T Lakey1, Tatsuya Kin, Garth L Warnock

  • 1Clinical Islet Transplant Program, University of Alberta and Capital Health Authority, Edmonton, Alberta, Canada. Jonlakey@rogers.blackberry.net

Cell Transplantation
|July 31, 2007
PubMed
Summary
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Simultaneous islet-kidney transplants offer hope for type 1 diabetes treatment. One patient showed sustained insulin secretion for 13 years, demonstrating long-term islet graft potential.

Area of Science:

  • Endocrinology
  • Transplantation Immunology
  • Metabolic Diseases

Background:

  • Type 1 diabetes mellitus (T1DM) management remains a challenge, with islet transplantation emerging as a potential therapeutic strategy.
  • Simultaneous islet-kidney transplantation addresses both end-stage renal disease and T1DM in select patients.
  • This study investigates long-term outcomes of islet transplantation in uremic T1DM patients.

Observation:

  • Two female patients with long-standing T1DM (27 and 37 years) underwent simultaneous islet-kidney transplantation.
  • Immunosuppression utilized a combination of steroids and cyclosporine.
  • A mix of freshly isolated and cryopreserved islets was transplanted into the liver via the portal vein.

Findings:

  • One patient achieved reasonable blood glucose control for up to 6 years, with limited clinical benefit at 10 years.

Related Experiment Videos

  • The second patient demonstrated sustained insulin secretion and near-normal HbA1c levels at 13 years post-transplant.
  • These results highlight variable, yet potentially significant, long-term islet graft function.

    • Implications:

    • Successful long-term islet graft function is achievable in select T1DM patients undergoing simultaneous transplantation.
    • Cryopreserved islets can be effectively utilized to supplement fresh islet mass.
    • These findings offer hope for improved long-term graft survival and glycemic control in islet transplant recipients.