Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toward nanoscale genome sequencing.

Declan Ryan1, Maryam Rahimi, John Lund

  • 1Department of Electrical Engineering, University of Washington Paul Allen Center, AE100R Box 352500 Seattle, WA 98195, USA.

Trends in Biotechnology
|July 31, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new frame shift pathogenic variant (c.773dupT) in the <i>BCKDHB</i> gene caused MSUD in an infant from north of Iran.

Case reports in perinatal medicine·2026
Same author

Aging in autism: A systematic review of cognitive, neural, and physical health findings.

Neuroscience and biobehavioral reviews·2026
Same author

Visual Cortical Response Variability in Infants at High Familial Likelihood for Autism.

bioRxiv : the preprint server for biology·2026
Same author

Thermal imaging in the extended shortwave infrared band.

Applied optics·2026
Same author

Advance Directive Completion Among Community-Dwelling Adults with Decompensated Cirrhosis.

Digestive diseases and sciences·2025
Same author

Effects of enhanced Melissa officinalis essential oil via carrageenan on mitigating aflatoxin b1-induced cytotoxicity in HT-29 and HEK-293 cells.

BMC complementary medicine and therapies·2025
Same journal

Engineering environmental bacteria for whole-cell PET hydrolysis and assimilation.

Trends in biotechnology·2026
Same journal

Acoustic cavitation-enhanced lymphatic trafficking of inhaled bacterial-sourced biohybrid vaccines for antitumor immunity.

Trends in biotechnology·2026
Same journal

Make uphill thermodynamics downhill in pathway design.

Trends in biotechnology·2026
Same journal

Engineering a capture-bioremediate-release microbial biofilm for simultaneous bioremediation of microplastics and adsorbed heavy metals.

Trends in biotechnology·2026
Same journal

Engineered bacterial biofilms for biotechnological applications.

Trends in biotechnology·2026
Same journal

Multiscale and programmable engineering of edible mushroom mycelium-based materials.

Trends in biotechnology·2026
See all related articles

Miniaturized devices are advancing DNA sequencing, offering cost reductions through

Area of Science:

  • Genomics and Molecular Biology
  • Nanotechnology
  • Bioengineering

Background:

  • Current DNA sequencing technologies face limitations in cost and scalability.
  • Miniaturization presents a pathway to more accessible genomic information.
  • Nanotechnology enables novel physical methods for nucleotide identification.

Purpose of the Study:

  • To review state-of-the-art miniaturized DNA sequencing technologies.
  • To explore the potential of 'on-chip' devices for cost reduction.
  • To identify challenges in achieving a US$1000-genome sequencing goal.

Main Methods:

  • Review of existing DNA sequencing technologies and their miniaturization.
  • Analysis of nano-scale structures and physical measurement techniques.

Related Experiment Videos

  • Assessment of novel approaches for direct nucleotide identification.

    • Main Results:

    • Miniaturization of DNA sequencing offers significant cost-reduction opportunities.
    • 'On-chip' devices leverage nano-scale effects for physical nucleotide identification.
    • Novel physical methods bypass traditional chemical sequencing approaches.

    Conclusions:

    • Miniaturized DNA sequencing is a rapidly evolving field with transformative potential.
    • Achieving a US$1000-genome target requires overcoming specific technological hurdles.
    • Nanotechnology-driven physical methods are key to future sequencing advancements.