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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Severe mitral annular calcification predicts chronic kidney disease.
Ammar Jesri1, Leonard E Braitman, Gregg S Pressman
1Department of Medicine, St. Francis Medical Center and Seton Hall University, Trenton, NJ, United States.
International Journal of Cardiology
|July 31, 2007
Summary
Severe mitral annular calcification (MAC) in cardiology patients may indicate underlying kidney dysfunction. This finding suggests MAC could serve as a marker for chronic kidney disease, particularly in those without kidney failure.
Area of Science:
- Cardiology
- Nephrology
- Medical Imaging
Background:
- Mitral annular calcification (MAC) is prevalent in elderly individuals and shares risk factors with atherosclerosis.
- MAC is frequently observed in patients undergoing dialysis.
- The study investigates MAC as a potential indicator of renal dysfunction in cardiology patients without kidney failure.
Purpose of the Study:
- To determine if severe mitral annular calcification (MAC) is associated with impaired kidney function in general cardiology patients.
- To explore the relationship between the severity of MAC and the degree of renal dysfunction.
Main Methods:
- Echocardiogram reports were searched to identify patients with severe MAC.
- Patients were categorized into subgroups based on the extent of calcification and mitral leaflet mobility.
- A control group with minimal or no intracardiac calcification was included for comparison.
Main Results:
- Patients with MAC exhibited significantly worse renal function (creatinine and glomerular filtration rate) compared to controls.
- Nearly 60% of MAC patients met criteria for chronic kidney disease (GFR < 60 ml/min/1.73 m²).
- A trend suggested declining GFR with increasing severity of MAC, with significantly lower GFR in the "MAC restricted" subgroup.
Conclusions:
- Severe MAC identified via echocardiography is strongly associated with chronic kidney disease.
- Further research is warranted to elucidate the graded relationship between MAC severity and renal dysfunction.
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