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Mouse Models of Periventricular Leukomalacia
Published on: May 18, 2010
Relationship between serum lactate level and periventricular leukomalacia
Hiroyuki Kidokoro1, Masaki Shimizu, Hirofumi Kimoto
1Department of Pediatrics, Anjo Kosei Hospital, 28 Tokoubann, Anjo-cho, Anjo-shi, Aichi 486-8510, Japan. kidokoro@wc4.so-net.ne.jp
Brain & Development
|July 31, 2007
Summary
Serum lactate levels were not elevated in preterm infants diagnosed with periventricular leukomalacia (PVL). This study suggests serum lactate is not a reliable predictor for developing PVL in newborns.
Area of Science:
- Neonatal research
- Pediatric neurology
- Biochemistry
Background:
- Periventricular leukomalacia (PVL) is a serious neonatal brain injury in preterm infants.
- Injury is presumed to occur around birth, but early biomarkers are needed.
- Serum lactate is a potential indicator of hypoxic injury.
Purpose of the Study:
- To evaluate serum lactate levels in preterm infants with PVL.
- To determine if serum lactate can predict PVL development.
Main Methods:
- Case-control study design.
- Included 13 preterm infants with cystic PVL and 26 controls matched for gestational age.
- Repeated serum lactate measurements within 72 hours of birth.
Main Results:
- No statistically significant difference in mean serum lactate levels between PVL and control groups.
- Lactate levels ranged from 2.95+/-0.43 mmol/L in PVL infants to 3.21+/-0.29 mmol/L in controls.
- No significant differences observed at any time point within the first 72 hours.
Conclusions:
- Serum lactate levels are not elevated in preterm infants with PVL.
- Serum lactate is not a useful predictor for the development of PVL.