Related Experiment Video
Updated: Jul 13, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
Published on: November 27, 2016
Response surface analysis of solution-mediated polymorphic transformation of buspirone hydrochloride
M Sheikhzadeh1, S Murad, S Rohani
1Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ont., Canada.
Abstract:
Buspirone hydrochloride has several polymorphs including Form 1 and Form 2. The solution-mediated transformation of Form 2 to Form 1 has been studied in this research. The interconversion of two polymorphs can occur in the salt formation step which is the last step for producing this drug. In addition, the effect of co-solvent and rate of addition of acid to the solution were investigated on the extent of interconversion of Form 2 to Form 1. It has been found that pH, co-solvent ratio and amount of solvent have more influence on polymorphic interconversion. A factorial design approach was used to carry out a response surface analysis to identify the more important factors affecting the interconversion of polymorphs and find the optimum experimental conditions for the production of the desired polymorph. Quantitative characterization of the product was done by XRPD, FT-IR, SEM, DSC and TSI-PSD.
More Related Videos
08:56Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
10:17Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Related Concept Videos
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Drug Biotransformation: Overview
Drug Biotransformation: Overview
Anxiolytic Drugs: Benzodiazepines and Buspirone
SN2 Reaction: Stereochemistry
If the substrate is an achiral molecule at the α-carbon, the inversion of configuration is not observed.