Discovery and optimization of p38 inhibitors via computer-assisted drug design
Daniel R Goldberg1, Ming-Hong Hao, Kevin C Qian
1Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., Research and Development Center, Ridgefield, Connecticut 06877, USA. dgoldber@rdg.boehringer-ingelheim.com
Journal of Medicinal Chemistry
|July 31, 2007
Abstract:
Integration of computational methods, X-ray crystallography, and structure-activity relationships will be disclosed, which lead to a new class of p38 inhibitors that bind to p38 MAP kinase in a Phe out conformation.
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