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Realization of immune response features by dynamical system models

Mika Yoshida1, Kinji Fuchikami, Tatsuya Uezu

  • 1Graduate School of Humanities and Sciences, Nara Women's University, Kitauoyahigashi-machi, Nara 630-8506, Japan. mika@ki-rin.phys.nara-wu.ac.jp

Mathematical Biosciences and Engineering : MBE
|July 31, 2007
PubMed

Among the features of real immune responses that occur when antigens invade a body are two remarkable features. One is that the number of antibodies produced in the secondary invasion by identical antigens is more than 10 times larger than in the primary invasion. The other is that more effective antibodies, which are produced by somatic hypermutation during the immune response, can neutralize the antigens more quickly. This phenomenon is called "affinity maturation". In this paper, we try to reproduce these features by dynamical system models and present possible factors to realize them. Further, we present a model in which the memory of the antigen invasion is realized without immune memory cells.

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