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Infectious complications and managements for surgical site infections in genital Paget's disease

O Yamasaki1, K Asagoe, M Otsuka

  • 1Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. kota616@cc.okayama-u.ac.jp

Journal of the European Academy of Dermatology and Venereology : JEADV
|July 31, 2007
PubMed
Abstract

Insights

Genital Paget's disease (GPD) surgery patients face infection risks. This study identified key perioperative microbes, including MRSA and Pseudomonas aeruginosa, aiding targeted antimicrobial therapy for better surgical outcomes.

Area of Science:

  • Oncology
  • Infectious Diseases
  • Microbiology

Background:

  • Extramammary Paget's disease is an intra-epidermal carcinoma primarily affecting genital areas.
  • Patients with genital Paget's disease (GPD) are susceptible to severe post-surgical infections due to anatomical factors.

Purpose of the Study:

  • To investigate perioperative microorganisms associated with GPD.
  • To determine the incidence, risk factors, and treatment of surgical site infections (SSI) in GPD patients.

Main Methods:

  • Microorganisms were isolated from preoperative lesions, necrotic sites, and infected wounds in 60 adult GPD patients undergoing surgery.
  • Microbiological data was analyzed to assess SSI incidence, risk factors, and treatment strategies.

Main Results:

  • Preoperative GPD isolates included Enterobacteriaceae (27.6%), methicillin-sensitive Staphylococcus aureus (MSSA) (22.4%), and coagulase-negative staphylococci (CNS) (15.5%).
  • Postoperatively, MSSA decreased (9.4%), while Pseudomonas aeruginosa (18.8%) and methicillin-resistant S. aureus (MRSA) (9.4%) increased.
  • The overall SSI incidence was 15%, with MRSA and/or P. aeruginosa identified in 7 out of 9 SSIs.

Conclusions:

  • Key perioperative microorganisms in GPD have been identified.
  • These findings are crucial for selecting effective antimicrobial agents in GPD surgical treatment.

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