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Development, characterization and evaluation of an auto-regulatory delivery system for insulin
S P Vyas1, J S Karajgi, P J Gogoi
1Department of Pharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya, Sagar, India.
Journal of Microencapsulation
|April 1, 1991
Abstract:
A self-regulatory delivery system for insulin was designed, based on the competitive and complementary binding behaviour of Concanavalin with glucose and glycosylated insulin. By encapsulating the Con-A bound G- insulin in a suitable polymer membrane, which was permeable to both glucose and insulin, the insulin efflux was regulated in response to glucose influx.