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Related Experiment Video

Updated: Jul 13, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

Enterococci and streptococci.

Sebastian G B Amyes¹

¹Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK. s.g.b.amyes@ed.ac.uk

International Journal of Antimicrobial Agents

|August 3, 2007

Summary

Multidrug-resistant Gram-positive bacteria, including enterococci and streptococci, pose significant treatment challenges. Tigecycline demonstrates broad in vitro susceptibility, suggesting its potential role in managing these difficult-to-treat infections.

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Published on: March 23, 2019

Area of Science:

Clinical microbiology
Infectious diseases
Antimicrobial resistance

Background:

Emergence of multidrug-resistant (MDR) Gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecium, Enterococcus faecalis, and Streptococcus spp., presents significant therapeutic challenges.
Vancomycin resistance in enterococci is a particular concern, leading to treatment failures.
Increasing resistance to common antibiotics like tetracyclines and macrolides is observed in Streptococcus spp.

Purpose of the Study:

To evaluate the in vitro susceptibility of multidrug-resistant Gram-positive bacteria to tigecycline.
To assess the potential of tigecycline as a therapeutic option for infections caused by these resistant pathogens.

Main Methods:

In vitro susceptibility testing of clinical isolates of Gram-positive bacteria, including enterococci and streptococci, against tigecycline.
Assessment of the propensity for resistance development to tigecycline in laboratory settings.

Main Results:

Multidrug-resistant strains of Enterococcus spp. and Streptococcus spp. showed considerable in vitro susceptibility to tigecycline.
Limited propensity for resistance development to tigecycline was observed in these bacterial groups.
Tigecycline represents a potential treatment option for infections caused by vancomycin-resistant enterococci and other MDR Gram-positive bacteria.

Conclusions:

Tigecycline exhibits promising in vitro activity against a range of multidrug-resistant Gram-positive bacteria.
The low propensity for resistance development suggests tigecycline could play a crucial role in combating challenging Gram-positive infections.
Further clinical evaluation is warranted to confirm the efficacy of tigecycline in treating infections caused by these resistant pathogens.