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Enterococci and streptococci

Sebastian G B Amyes1

  • 1Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK. s.g.b.amyes@ed.ac.uk

International Journal of Antimicrobial Agents
|August 3, 2007
PubMed

Insights

Multidrug-resistant Gram-positive bacteria, including enterococci and streptococci, pose significant treatment challenges. Tigecycline demonstrates broad in vitro susceptibility, suggesting its potential role in managing these difficult-to-treat infections.

Area of Science:

  • Clinical microbiology
  • Infectious diseases
  • Antimicrobial resistance

Background:

  • Emergence of multidrug-resistant (MDR) Gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecium, Enterococcus faecalis, and Streptococcus spp., presents significant therapeutic challenges.
  • Vancomycin resistance in enterococci is a particular concern, leading to treatment failures.
  • Increasing resistance to common antibiotics like tetracyclines and macrolides is observed in Streptococcus spp.

Purpose of the Study:

  • To evaluate the in vitro susceptibility of multidrug-resistant Gram-positive bacteria to tigecycline.
  • To assess the potential of tigecycline as a therapeutic option for infections caused by these resistant pathogens.

Main Methods:

  • In vitro susceptibility testing of clinical isolates of Gram-positive bacteria, including enterococci and streptococci, against tigecycline.
  • Assessment of the propensity for resistance development to tigecycline in laboratory settings.

Main Results:

  • Multidrug-resistant strains of Enterococcus spp. and Streptococcus spp. showed considerable in vitro susceptibility to tigecycline.
  • Limited propensity for resistance development to tigecycline was observed in these bacterial groups.
  • Tigecycline represents a potential treatment option for infections caused by vancomycin-resistant enterococci and other MDR Gram-positive bacteria.

Conclusions:

  • Tigecycline exhibits promising in vitro activity against a range of multidrug-resistant Gram-positive bacteria.
  • The low propensity for resistance development suggests tigecycline could play a crucial role in combating challenging Gram-positive infections.
  • Further clinical evaluation is warranted to confirm the efficacy of tigecycline in treating infections caused by these resistant pathogens.

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