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Updated: Jul 13, 2026
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Interstitial stereotactic radiosurgery of pilocytic astrocytomas in paediatric patients
E J Herrera1, J C Viano, J M Gómez
1Department of Stereotactic and Functional Neurosurgery, Sanatorio Allende, Cordoba, Argentina. hmaldonado@arnet.com.ar
Objective:
To evaluate the clinical presentation, tumour response, clinical improvement and complications in 12 children and young people with a pilocytic astrocytoma, WHO I grade 1, who were treated with interstitial radiosurgery using Iodine-125 seed implants.
Patients And Methods:
Retrospective analysis of 12 patients aged under 18 years (mean 8.4 years, ranging from 8 months to 17 years of age) with a pilocytic astrocytoma treated between 1993 and 2006. Iodine-125 seeds were used as temporary implants with low-dose rate (
Results:
There was no perioperative mortality. Two patients worsened transiently, but thereafter each patient improved clinically. Eleven out of 12 tumours shrank after the treatment. The mean volume of the tumours before implantation was 17.9 cm(3). and was reduced to 60% of this volume at 6 months, to 26.5% at 12 months, to 8% at 24 months, and was less than 1% at 30-36 months One patient underwent a reimplantation to treat a recurrence 3 years after the initial treatment. Ten patients were alive 2 years after the first intervention. In the longest surving patient, there was no evidence of progression after 13.4 years of follow up.
