Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Renal involvement in systemic sclerosis].

S Guerini1, I Cavazzana, C Venturelli

  • 1Cattedra e Divisione di Nefrologia, Università e Spedali Civili, Brescia.

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|July 31, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of vancomycin resistance on attributable mortality among Enterococcus faecium bloodstream infections: propensity score analysis of a large, multicentre retrospective study.

The Journal of antimicrobial chemotherapy·2025
Same author

Intraoperative nerve monitoring in thyroid and parathyroid surgery: a decade of Italian practice.

Updates in surgery·2025
Same author

Pregnancy in patients affected by axial-spondyloarthritis: a narrative review of disease activity and obstetric outcomes.

Reumatismo·2024
Same author

Evaluation of a large set of patients with Autoimmune Polyglandular Syndrome from a single reference centre in context of different classifications.

Journal of endocrinological investigation·2023
Same author

The challenge of diagnosing atheroembolic renal disease clinical features and prognostic factors. Circulation 116: 298-304, 2007.

Clinical journal of the American Society of Nephrology : CJASN·2023
Same author

Laparoscopic approach in emergency for the treatment of acute incarcerated groin hernia: a systematic review and meta-analysis.

Hernia : the journal of hernias and abdominal wall surgery·2022
Same journal

[Rufus of Ephesus, On gout].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2026
Same journal

A Case Report and Literature Review: Chlorhexidine-induced anaphylaxis in a hemodialysis patient.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2026
Same journal

New Frontiers in the Treatment of Chronic Kidney Disease-associated Pruritus: A Case of Hemoperfusion with HA130.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2026
Same journal

Fibronectin Glomerulopathy: A Case Report of Membranoproliferative Glomerulonephritis.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2026
Same journal

Sodium Disorders in Multiple Myeloma: Beyond Pseudohyponatremia to Clinical Pitfalls and Mechanistic Insights.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2026
Same journal

Acute Kidney Injury and Early Diagnostic Biomarkers: A Narrative Literature Review.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2026
See all related articles

Systemic sclerosis can cause kidney problems like renal crisis, affecting 10-40% of patients. Early monitoring of renal function is crucial, especially for those with diffuse skin disease, as kidney involvement worsens prognosis.

Area of Science:

  • Nephrology
  • Rheumatology
  • Autoimmune Diseases

Context:

  • Systemic sclerosis is an autoimmune disease causing fibrosis.
  • Raynaud's phenomenon often precedes other symptoms.
  • Classified into limited and diffuse forms based on skin and organ involvement.

Purpose:

  • To describe the spectrum of renal involvement in systemic sclerosis.
  • To highlight the clinical presentations and outcomes of renal complications.
  • To emphasize the importance of monitoring renal function in these patients.

Summary:

  • Renal disease affects 10-40% of systemic sclerosis patients, most commonly as renal crisis (acute renal failure, hypertension).
  • Other renal manifestations include chronic nephropathy, penicillamine-induced nephrotic syndrome, and ANCA-associated glomerulonephritis.

Related Experiment Videos

  • Despite ACE inhibitor treatment, 20-50% of renal crisis patients progress to end-stage renal disease.

    • Impact:

    • Renal involvement in systemic sclerosis is associated with a worse prognosis.
    • Close monitoring of blood pressure, urine, and renal function is essential, particularly in diffuse systemic sclerosis.
    • Evidence supports prostacyclin derivatives, antifibrotic, and immunosuppressive drugs, alongside ACE inhibitors for renal crisis, as disease-modifying therapies.