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Updated: Jul 13, 2026
Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
Published on: September 14, 2014
Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin
Andrea Marzi1, Daniel A Mitchell, Chawaree Chaipan
1Institute for Clinical and Molecular Virology, University Hospital Erlangen, 91054 Erlangen, Germany.
Abstract:
The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.
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