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Non compaction cardiomyopathy and Antiphospholipid syndrome: a catastrophic thromboembolic association

Pietro Pugliatti, Gianluca Di Bella, Antonino Recupero

    International Journal of Cardiology
    |July 31, 2007
    PubMed

    Insights

    Antiphospholipid syndrome can cause massive non-compaction cardiomyopathy, leading to severe left ventricular dysfunction. This rare association dramatically increases the risk of thromboembolic events, including stroke.

    Area of Science:

    • Cardiology
    • Rheumatology
    • Neurology

    Background:

    • Antiphospholipid syndrome is an autoimmune disorder associated with an increased risk of thrombosis.
    • Non-compaction cardiomyopathy is a rare congenital heart muscle disease characterized by excessive trabeculation.

    Observation:

    • A 53-year-old male presented with recurrent ischemic cerebral strokes, functional disability, cognitive decline, and vascular dementia.
    • The patient was diagnosed with massive non-compaction cardiomyopathy and Antiphospholipid syndrome.

    Findings:

    • The co-occurrence of massive non-compaction cardiomyopathy and Antiphospholipid syndrome in this patient led to severe left ventricular dysfunction.
    • This combination resulted in a dramatic presentation of thromboembolic manifestations.

    Implications:

    • This case highlights a potentially underrecognized association between non-compaction cardiomyopathy and Antiphospholipid syndrome.
    • Early recognition and management of Antiphospholipid syndrome may be crucial in patients with non-compaction cardiomyopathy to prevent severe thromboembolic events.

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