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Updated: Jul 13, 2026

Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria
Published on: January 7, 2022
Delivery of drugs and macromolecules to mitochondria
Abhijit Mukhopadhyay1, Henry Weiner
1Department of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907-2063, USA. mukhopad@purdue.edu
Abstract:
Mitochondria is where the bulk of the cell's ATP is produced. Mutations occur to genes coding for members of the complexes involved in energy production. Some are a result of damages to nuclear coded genes and others to mitochondrial coded genes. This review describes approaches to bring small molecules, proteins and RNA/DNA into mitochondria. The purpose is to repair damaged genes as well as to interrupt mitochondrial function including energy production, oxygen radical formation and the apoptotic pathway.
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