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Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis
W B Graninger1, W Hassfeld, B B Pesau
12nd Department of Internal Medicine, University of Vienna, Austria.
The Journal of Rheumatology
|October 1, 1991
Abstract:
The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis. In addition to glomerulonephritis and a butterfly rash, previously negative tests for antinuclear, anti-dsDNA and anti-Sm antibodies became positive. We assume that rIFN-gamma induced the de novo development of SLE in our patient.