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Updated: Jul 13, 2026

Label-Free Imaging of Lipid Storage Dynamics in Caenorhabditis elegans using Stimulated Raman Scattering Microscopy
Published on: May 28, 2021
Caenorhabditis elegans SDF-9 enhances insulin/insulin-like signaling through interaction with DAF-2
Victor L Jensen1, Patrice S Albert, Donald L Riddle
1Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Abstract:
SDF-9 is a modulator of Caenorhabditis elegans insulin/IGF-1 signaling that may interact directly with the DAF-2 receptor. SDF-9 is a tyrosine phosphatase-like protein that, when mutated, enhances many partial loss-of-function mutants in the dauer pathway except for the temperature-sensitive mutant daf-2(m41). We propose that SDF-9 stabilizes the active phosphorylated state of DAF-2 or acts as an adaptor protein to enhance insulin-like signaling.
