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Updated: Jul 13, 2026

Modification of the Treatment Methods for Wasting Marmoset Syndrome with Tranexamic Acid and Supportive Measures
Published on: July 12, 2024
[Causes and treatment of hypomagnesemia]
Masahiro Yamamoto1, Toru Yamaguchi
1Shimane University Faculty of Medicine, Department of Internal Medicine 1, Japan.
None:
Plasma magnesium (Mg) is known to be maintained within a normal range through its gastrointestinal absorption as well as renal excretion, and disturbances at these sites might cause hypomagnesemia. Mg balance is most susceptible to the malfunction of the thick ascending limb of renal tubules, because 70% of urinary Mg excretion is reabsorbed from this site. Investigation of hypomagnesemia-exhibiting inherited diseases revealed molecular mechanisms of Mg transport pathways; paracellin-1 as a passive paracellular transport and TRPM6 as an active transcellular transport. Mild and severe hypomagnesemia are treated with oral replacement such as magnesium oxide, as well as intravenous administration of magnesium sulfate.
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