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Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
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Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

[Effect of angiogenesis inhibitors on renal cell carcinoma]

István Bodrogi1

  • 1Országos Onkológiai Intézet, Budapest. bodrogi@oncol.hu

Magyar Onkologia
|July 31, 2007
PubMed

Insights

Angiogenesis inhibitors are the most effective treatment for advanced renal cell carcinoma. New targeted therapies and combination treatments are needed for different stages of clear cell renal cell cancer.

Area of Science:

  • Oncology
  • Medical Science

Background:

  • Sporadic renal cell carcinomas exhibit Epidermal Growth Factor Receptor (EGFR/HER-1) and EGFR-2 (HER-2) expression, but pathway inhibitors showed limited clinical efficacy.
  • Clear cell renal cell cancer is resistant to hormone, irradiation, and chemotherapy, with only moderate sensitivity to immunotherapy.

Purpose of the Study:

  • To review the clinical effectiveness of various treatment modalities for renal cell carcinoma.
  • To highlight the emergence of anti-angiogenic agents as a key therapeutic class.

Main Methods:

  • Review of clinical trial data and regulatory approvals for renal cell carcinoma treatments.
  • Analysis of treatment outcomes for different risk groups and stages of clear cell renal cell cancer.

Main Results:

  • Angiogenesis inhibitors, such as sorafenib and sunitinib, have been approved for first- and second-line treatments.
  • Temsirolimus is approved for high-risk renal cell cancer patients.
  • Bevacizumab is nearing FDA approval for renal cell cancer treatment.

Conclusions:

  • Angiogenesis inhibitors represent the most effective therapeutic class for renal cell carcinoma to date.
  • Development of diverse treatment strategies tailored to various stages of clear cell renal cell cancer progression is crucial.

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