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[Expression of Livin mRNA and protein in human oral squamous cell carcinoma]
Zhi-hong Zong1, De-hao Shang, Chang-fu Sun
1Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China.
Purpose:
To investigate the expression of the newly found inhibitor of apoptosis protein Livinalpha and Livinbeta and their gene expression in human oral squamous cell carcinoma.
Methods:
Twenty specimens of human squamous cell carcinoma(SCC), 15 cases of benign cysts, 10 cases of normal oral mucosal tissues adjacent to the cancerous lesions were examined. Polymerase chain reaction with reverse transcription (RT-PCR) and Western blot analysed were used to detect mRNA and protein expression of Livin, respectively.The results were analysed by SPSS10.0 software package.
Results:
Livin protein and mRNA expression was detected in 19 SCC tissues,14 benign cysts and 10 normal oral mucosal tissues adjacent to the cancerous lesions.But the expressions were significantly higher in oral SCC than in benign cysts and normal oral mucosal tissues (P<0.01).
Conclusion:
Livin may play an important role in the tumorigenesis and development of human oral squamous cell carcinoma.