[Drug induced hepatitis following sevoflurane anesthesia in a child]

A new volatile anesthetic, sevoflurane, is widely used in Japan. We first report a patient who developed liver dysfunction following sevoflurane anesthesia. He had a resection of the bilateral extra toes at the age of eleven months. Although no problems occurred during the operation, he had serious liver dysfunction. Fourteen days after operation, serum GOT was elevated to the maximum of 836U. The pathogenesis is considered to be related to sevoflurane anesthesia, because viral hepatitis was excluded, and sevoflurane is considerably positive in lymphocyte stimulation test in contrast with antibiotics.