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Embedded Bioprinting of Tissue-like Structures Using κ-Carrageenan Sub-Microgel Medium
Published on: May 3, 2024
Depolymerized products of lambda-carrageenan as a potent angiogenesis inhibitor.
Haimin Chen1, Xiaojun Yan, Jing Lin
1Key Laboratory of Marine Biotechnology, Ningbo University, Post Box 71, Ningbo, Zhejiang 315211, China. haiminch75@yahoo.com.cn
Journal of Agricultural and Food Chemistry
|July 31, 2007
Summary
Low-molecular-weight lambda-carrageenan oligosaccharides (lambda-CO) show significant anti-angiogenesis effects. This compound inhibits vessel growth, invasion, and migration, indicating potential as an angiogenesis inhibitor.
Area of Science:
- Biochemistry
- Cell Biology
- Pharmacology
Background:
- Angiogenesis is crucial in diseases like cancer and cardiovascular events.
- Identifying novel angiogenesis inhibitors is a key research area.
Purpose of the Study:
- To evaluate the anti-angiogenic potential of low-molecular-weight, highly sulfated lambda-carrageenan oligosaccharides (lambda-CO).
Main Methods:
- Chick chorioallantoic membrane (CAM) model.
- In vitro studies using human umbilical vein endothelial cells (HUVECs).
- Histochemistry assays, cell viability, invasion, and migration assays.
- Analysis of matrix metalloproteinase-2 (MMP-2) expression.
Main Results:
- Significant inhibition of vessel growth observed at 200 microg/pellet in the CAM model.
- lambda-CO decreased capillary plexus and connective tissue.
- Inhibited HUVEC viability at high concentrations, with slight effects at low concentrations.
- Reduced endothelial cell invasion and migration at 150-300 microg/mL by down-regulating MMP-2 expression.
Conclusions:
- lambda-CO demonstrates significant anti-angiogenic properties.
- It acts by inhibiting endothelial cell proliferation, invasion, and migration.
- lambda-CO is a promising candidate for developing novel angiogenesis inhibitors.
