Extended-spectrum cephalosporinases: structure, detection and epidemiology
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Patrice Nordmann1, Hedi Mammeri
1Service de Bactériologie-Virologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France. nordmann.patrice@bct.aphp.fr
Abstract:
Extended-spectrum AmpC beta-lactamases of Enterobacteriaceae, which are chromosomally or plasmid-encoded, possess structural modifications in the vicinity of the active site compared with their progenitors. They display an increased catalytic efficiency against extended-spectrum beta-lactams, such as ceftazidime, cefotaxime, cefepime, cefpirome and, in some cases, also against imipenem. An overview of the molecular and biochemical characterization of this recently identified mechanism of resistance to beta-lactams is provided as well as its prevalence and possible clinical significance.
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