Related Experiment Video
Updated: Jul 13, 2026
06:15
A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
Published on: June 14, 2015
BioGlue: a protective barrier after pericardiotomy
Nai Dong Wang1, Donald B Doty, John R Doty
1Division of Cardiovascular and Thoracic Surgery, LDS Hospital, Salt Lake City, Utah, USA.
Journal of Cardiac Surgery
|July 31, 2007
Summary
A novel BioGlue sheet effectively prevents sternal adhesion after heart surgery by promoting a unique connective tissue barrier. This barrier reduces scarring, improving outcomes for repeat cardiac operations.
Area of Science:
- Biomaterials Science
- Cardiovascular Surgery
- Regenerative Medicine
Background:
- Repeat cardiac surgeries account for approximately 20% of procedures.
- Preventing cardiac adhesion to the sternum is a clinical need.
Purpose of the Study:
- To evaluate the efficacy of a milled BioGlue sheet in preventing cardiac adhesion.
- To assess the tissue response to BioGlue as a barrier material.
Main Methods:
- Anterior pericardiectomy was performed in rats.
- Milled BioGlue sheets were applied to the heart surface in experimental groups.
- Control groups received Surgicel alone or no treatment.
- Adhesion, scarring, and material presence were assessed at 1, 3, and 6 months.
Main Results:
- Milled BioGlue promoted a loose connective tissue barrier with vascularization and no scar formation.
- Surgicel with BioGlue and Surgicel alone formed denser connective tissue barriers.
- No barrier formed in control subjects.
Conclusions:
- A milled BioGlue sheet applied to the heart surface stimulates a unique loose connective tissue barrier.
- This barrier differs from dense fibrous scar tissue typically seen after pericardial procedures.
- BioGlue shows potential as a material to prevent adhesions in cardiac surgery.
