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Related Experiment Video

Updated: Jul 13, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Serotonin 5HT1A receptor availability and pathological crying after stroke.

M Møller¹, G Andersen, A Gjedde

¹Center of Functionally Integrative Neuroscience, Aarhus University, Denmark. moller@pet.auh.dk

Acta Neurologica Scandinavica

|July 31, 2007

Summary

Pathological crying after stroke may stem from serotonin depletion, increasing 5-HT(1A) receptor binding. Selective serotonin re-uptake inhibitor (SSRI) treatment can reverse these changes, suggesting a new therapeutic avenue.

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Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

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Published on: January 9, 2026

Area of Science:

Neuroscience
Radiology
Pharmacology

Background:

Post-stroke depression and pathological crying are linked to altered serotonergic neurotransmission.
Serotonin depletion is hypothesized to increase 5-HT(1A) receptor binding potential.

Purpose of the Study:

To investigate changes in serotonergic neurotransmission in patients with acute stroke and pathological crying.
To assess the effect of selective serotonin re-uptake inhibitor (SSRI) treatment on these changes.

Main Methods:

Positron emission tomography (PET) scans were performed on patients with acute stroke and pathological crying and age-matched controls.
Receptor availability maps were generated for cortical regions and raphe nuclei using [carbonyl-(11)C]WAY-100635.

Main Results:

Baseline binding potentials were lower in patients compared to controls (3.7 +/- 0.6 vs 4.2 +/- 0.2).
SSRI treatment significantly reduced free receptor sites, indicating increased serotonin transporter availability.
Placebo administration resulted in a global increase in binding potential.

Conclusions:

This study provides the first evidence of altered serotonergic neurotransmission in the early stages of stroke.
SSRI treatment effectively modulates these neurochemical changes, offering potential therapeutic benefits for post-stroke mood disorders.