Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffusion-weighted imaging in brain aspergillosis.

M Charlot1, J-B Pialat, N Obadia

  • 1Department of Radiology, Claude Bernard University, Hospices Civils de Lyon, Lyon, France.

European Journal of Neurology
|July 31, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Racial Disparities in the Prescribing of Guideline-Recommended Medications for Metastatic Prostate Cancer: A Retrospective Cohort Study.

Prostate cancer·2025
Same author

Predicting cervico-thoraco-lumbar vertebra positions from cutaneous markers: Combining local frame and postural predictors improves robustness to posture.

Journal of biomechanics·2024
Same author

Months-long seismicity transients preceding the 2023 M<sub>W</sub> 7.8 Kahramanmaraş earthquake, Türkiye.

Nature communications·2023
Same author

Protein binding investigation of first-line and second-line antituberculosis drugs.

International journal of antimicrobial agents·2023
Same author

Identification of demyelinating lesions and application of McDonald criteria when confronted with white matter lesions on brain MRI.

Revue neurologique·2023
Same author

Intramedullary abscess secondary to infective endocarditis presenting as longitudinally extensive transverse myelopathy.

Revue neurologique·2022

Diffusion-weighted imaging (DWI) reveals characteristic patterns in brain aspergillosis, aiding early diagnosis. These findings help differentiate fungal infections from other brain lesions in immunocompromised patients.

Area of Science:

  • Neurology
  • Radiology
  • Infectious Diseases

Background:

  • Brain aspergillosis is a rare, severe infection primarily affecting immunocompromised individuals, often causing cerebral infarctions.
  • Magnetic resonance (MR) imaging is used to diagnose brain aspergillosis, but diffusion-weighted imaging (DWI) findings, particularly in non-enhancing lesions, are less understood.
  • Early diagnosis is crucial for timely antifungal treatment to improve patient outcomes.

Observation:

  • This study analyzed MR imaging, including DWI and apparent diffusion coefficient (ADC) mapping, in three patients with brain aspergillosis.
  • A total of 23 circular lesions were observed across the patients, with one also showing an infarction in the middle cerebral artery territory.
  • Lesions exhibited varied enhancement patterns: one ring-enhancing, two non-enhancing.

Related Experiment Videos

Findings:

  • Eleven lesions showed high signal intensity on DWI with reduced ADC values.
  • Twelve lesions displayed a 'target-like' appearance on DWI, with central and peripheral hypointense areas (higher ADC) and intermediate hypersignal.
  • This 'target-like' DWI appearance is a typical finding in brain aspergillosis.

Implications:

  • The characteristic DWI 'target-like' sign can facilitate early diagnosis of brain aspergillosis.
  • This imaging finding is valuable for differentiating aspergillosis from other infectious or malignant brain lesions in immunocompromised patients.
  • Earlier diagnosis via DWI may enable prompt initiation of antifungal therapy, potentially improving prognosis.