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Related Experiment Video

Updated: Jul 13, 2026

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes

Published on: March 2, 2020

Fourth-generation fluoroquinolone-resistant bacterial keratitis.

Vishal Jhanji¹, Namrata Sharma, Gita Satpathy

¹Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Journal of Cataract and Refractive Surgery

|July 31, 2007

Summary

This case study details keratitis caused by Staphylococcus epidermidis, a coagulase-negative Staphylococcus. The bacteria showed resistance to moxifloxacin, highlighting treatment challenges in infectious keratitis.

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Area of Science:

Ophthalmology
Microbiology
Infectious Diseases

Background:

Keratitis, an inflammation of the cornea, can be caused by bacterial infections.
Coagulase-negative Staphylococcus (CoNS), particularly Staphylococcus epidermidis, is a common cause of ocular infections.
Antibiotic resistance in bacterial keratitis poses a significant challenge to effective treatment.

Observation:

Corneal scrapings from a patient with keratitis were analyzed microbiologically.
Staphylococcus epidermidis was identified as the causative agent.
Antibiotic susceptibility testing revealed resistance to moxifloxacin, gatifloxacin, ciprofloxacin, and cefazolin.

Findings:

The identified Staphylococcus epidermidis isolate was susceptible to vancomycin, tobramycin, and gentamicin.
The patient's treatment was adjusted based on the antibiotic sensitivity results.
This case highlights a strain of Staphylococcus epidermidis causing keratitis resistant to moxifloxacin.

Implications:

Clinicians should be aware of potential antibiotic resistance patterns in Staphylococcus epidermidis keratitis.
Tailoring antibiotic therapy based on susceptibility testing is crucial for successful treatment outcomes.
Further research into emerging resistance mechanisms in ocular pathogens is warranted.