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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
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Helicobacter pylori primary resistant strains over 11 years in French children

Nicolas Kalach1, Lydia Serhal, Edgar Asmar

  • 1Clinique de Pédiatrie Saint Antoine, Hôpital Saint Vincent de Paul, BD de Belfort, Université Catholique de Lille, 59020 Lille, France.

Diagnostic Microbiology and Infectious Disease
|July 31, 2007
PubMed

Insights

Prevalence of Helicobacter pylori resistance in children showed stable clarithromycin resistance but a significant decrease in metronidazole resistance between 1994 and 2005.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • Helicobacter pylori infection is a significant global health concern, particularly in children.
  • Antibiotic resistance in H. pylori complicates treatment and impacts eradication success rates.
  • Monitoring resistance patterns is crucial for effective therapeutic strategies.

Purpose of the Study:

  • To investigate the trends in primary antibiotic resistance of H. pylori strains isolated from children.
  • To assess the prevalence of resistance to amoxicillin, metronidazole, and clarithromycin over a 12-year period.

Main Methods:

  • A retrospective analysis of 377 H. pylori strains isolated from children between 1994 and 2005.
  • Antimicrobial susceptibility testing was performed for amoxicillin, metronidazole, and clarithromycin.
  • Statistical analysis was used to determine resistance trends over time.

Main Results:

  • All strains were susceptible to amoxicillin.
  • Metronidazole resistance decreased significantly from 43.3% (1994-1998) to 32% (1999-2005) (P = 0.001).
  • Clarithromycin resistance remained stable at 22.8% throughout the study period. Resistance to both drugs was 7.9%.

Conclusions:

  • Metronidazole resistance in pediatric H. pylori strains has shown a declining trend.
  • Clarithromycin resistance remains a significant concern, with no observed decrease.
  • Continued surveillance of antibiotic resistance patterns in H. pylori is essential for optimizing pediatric treatment regimens.

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